Heterologous Expression and Manipulation of Three Tetracycline Biosynthetic Pathways
| Autor: | Yi Tang, Xue Gao, Woncheol Kim, Peng Wang, Lauren B. Pickens |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Chlortetracycline
chemistry.chemical_classification Molecular Structure biology Tetracycline Heterologous Oxytetracycline General Medicine General Chemistry biology.organism_classification Streptomyces Article Catalysis Polyketide Enzyme chemistry Biochemistry Tetracyclines medicine Heterologous expression Gene Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Angewandte Chemie International Edition. 51:11136-11140 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201205426 |
| Popis: | A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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