CT-guided laser therapy in resistant human tumors: phase I clinical trials
| Autor: | William H. Hartz, J S Rosenblum, P J Moldofsky, Michael Clair, Paul F. Engstrom, Robert A. Gatenby, N.D. Hammond, G J Broder, Evan C. Unger, Howard Kessler |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Photodynamic therapy Catheterization chemistry.chemical_compound Laser therapy Neoplasms medicine Fiber Optic Technology Humans Radiology Nuclear Medicine and imaging In patient Hematoporphyrin Photoradiation Hematoporphyrin business.industry Surgery Clinical trial Catheter chemistry Photochemotherapy Toxicity Drug Evaluation Laser exposure business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | Radiology. 163(1) |
| ISSN: | 0033-8419 |
| Popis: | Photodynamic therapy was performed on ten tumors in patients who did not respond to initial therapy and for whom no additional conventional therapy was available. A sensitizing agent (hematoporphyrin derivative [HpD]) was injected directly into each tumor under computed tomographic (CT) guidance to deliver high concentrations to the tumor and to minimize systemic toxicity. Three to 6 days after the injection, a clear Teflon sheath catheter was placed into the tumor under CT guidance. The tumor was exposed to red light (630-nm wavelength) through laser fiberoptics inserted in the sheath. The initial investigation confirmed the technical feasibility of CT-guided photodynamic therapy by means of intratumoral HpD injections and laser exposure through fiberoptics inserted in sheath catheters. The toxicity from a single treatment was minor, and the tumor response was encouraging. |
| Databáze: | OpenAIRE |
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