Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model
| Autor: | Richard J. Knapp, Ewa Malatynska, Alicia Cecil, Caroline Shuck, Glenda Crites, Rachel Goldenberg, Cortland Miller, Jeff Watkins |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Competitive Behavior medicine.drug_class Dioxoles Pharmacology Anxiolytic Nootropic Rats Sprague-Dawley Piperidines Fluoxetine medicine Animals Psychiatry Maze Learning Nootropic Agents Diazepam Dose-Response Relationship Drug Desipramine Piracetam Antidepressive Agents Pyrrolidinones Aniracetam Rats Mechanism of action Models Animal Antidepressant medicine.symptom Psychology Injections Intraperitoneal medicine.drug |
| Zdroj: | European journal of pharmacology. 440(1) |
| ISSN: | 0014-2999 |
| Popis: | The present study tests the activity of nootropic drugs in a behavioral test linked to depression. This test measures the reduction of submissive behavior in a competition test as the relative success of two food-restricted rats to gain access to a feeder. Nootropic drugs tested include piracetam (2-oxo-1-pyrrolidineacetamide), aniracetam (1-(4-methoxybenzoyl)-2-pyrrolidinone), the Ampakine™, Ampalex™, 1-(quinoxalin-6-ylcarbonyl)piperidine, and analogs were compared to the antidepressants, fluoxetine ((±)-N-methyl-gamma-(4-[trifluoromethyl]phenoxy)-benzenepropanamine) and desimpramine (5H-dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride), while the anxiolytic diazepam (7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one) served as a control. Drugs were given intraperitoneally for 3 weeks. The antidepressant and nootropic drugs reduced submissive behavior over time. The effect was dose dependent as measured for fluoxetine and Ampakines. The reduction of submissive behavior by Ampakines gradually faded after cessation of treatment and had a more rapid onset of activity (during the 1st week of treatment) than fluoxetine (after 2 weeks). The results suggest that Ampakines may have antidepressant activity. The potential of depression treatment with memory-enhancing drugs is hypothesized and the link between cognition and depression is discussed. |
| Databáze: | OpenAIRE |
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