Curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation
| Autor: | Wu Luo, Jianpeng Feng, Krishna K. Singh, Yi Wang, Hanghui He, Xueting Hu, Sihui Yin, Shanshan Hong, Lin Ye, Bin Yang, Jianqiang Chen, Guang Liang, Xiang Hu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Curcumin MAP Kinase Signaling System Kidney Glomerulus Anti-Inflammatory Agents Apoptosis Inflammation RM1-950 Pharmacology Diet High-Fat Diabetic nephropathy Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glomerulopathy Fibrosis Chronic kidney disease medicine Animals Obesity Triglycerides business.industry NF-kappa B General Medicine medicine.disease Mice Inbred C57BL Cholesterol 030104 developmental biology chemistry 030220 oncology & carcinogenesis Chronic Disease Cytokines Kidney Diseases Therapeutics. Pharmacology medicine.symptom Signal transduction business C66 Kidney disease |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111418-(2021) |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2021.111418 |
| Popis: | Obesity has been recognized as a major risk factor for the development of chronic kidney disease, which is accompanied by increased renal inflammation, fibrosis, and apoptosis. C66 is a curcumin derivative that exerts anti-inflammatory effects by inhibiting the JNK pathway and prevents diabetic nephropathy. The present study investigates the possible protective effect of C66 on high-fat diet (HFD)-induced obesity-related glomerulopathy. Mice were fed with HFD for 8 weeks while some were treated with C66 every 2 days for 11 weeks. The HFD-fed mice developed renal dysfunction, as well as elevated triglyceride and cholesterol. Kidneys of the HFD-fed mice showed marked glomerular injuries, apoptosis, and inflammation with markedly increased cytokine production. Interestingly, treating HFD-fed mice with C66 remarkably reversed these pathological changes via inhibiting inflammation and NF-κB/JNK activation. In cultured mesangial cells, Palmitic Acid was able to activate the pro-fibrotic mechanisms, apoptosis, inflammatory response, and NF-κB and JNK signaling pathways, all of which could be attenuated by C66 treatment. In all, we demonstrated that curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation and apoptosis via targeting NF-κB and JNK. Our data suggest that C66 can be potentially used to prevent obesity-associated renal diseases warranting future investigations. |
| Databáze: | OpenAIRE |
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