NMR and MRI of Blood-Dissolved Hyperpolarized Xe-129 in Different Hollow-Fiber Membranes
| Autor: | Bernhard Blümich, Nadia Amor, Stephan Appelt, Thomas Schmitz-Rode, Kathrin Hamilton, Ulrich Steinseifer, Markus Küppers |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Surface Properties Swine Analytical chemistry chemistry.chemical_element Polyenes Hemoglobins Xenon Nuclear magnetic resonance Animals Fiber Physical and Theoretical Chemistry Solubility Porosity Spectroscopy Dissolution Chemistry digestive oral and skin physiology technology industry and agriculture Membranes Artificial Equipment Design Nuclear magnetic resonance spectroscopy equipment and supplies Magnetic Resonance Imaging Atomic and Molecular Physics and Optics Oxygen Solutions Membrane Xenon Isotopes |
| Zdroj: | ChemPhysChem. 12:2941-2947 |
| ISSN: | 1439-4235 |
| Popis: | Magnetic resonance of hyperpolarized (129)Xe has found a wide field of applications in the analysis of biologically relevant fluids. Recently, it has been shown that the dissolution of hyperpolarized gas into the fluid via hollow-fiber membranes leads to bubble-free (129)Xe augmentation, and thus to an enhanced signal. In addition, hollow-fiber membranes permit a continuous operation mode. Herein, a quantitative magnetic resonance imaging and spectroscopy analysis of a customized hollow-fiber membrane module is presented. Different commercial hollow-fiber membrane types are compared with regard to their (129)Xe dissolution efficiency into porcine blood, its constituents, and other fluids. The presented study gives new insight into the suitability of these hollow-fiber membrane types for hyperpolarized gas dissolution setups. |
| Databáze: | OpenAIRE |
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