Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Autor: Johanna Liinamaa, Elina Karvonen, Eero Castrén, Laura Lindberg, J. Matias Palva, Ville Saarela, Marja-Leena Latvala, Henri J. Huttunen, Satu Palva, Hannu Uusitalo, Sigrid Booms
Přispěvatelé: Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere, Doctoral Programme Brain & Mind, Doctoral Programme in Drug Research, Henri Juhani Huttunen / Principal Investigator, Neuroscience Center, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Matias Palva / Principal Investigator, Silmäklinikka, Clinicum, Eero Castren / Principal Investigator
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Pediatrics
Visual acuity
TREAT AMBLYOPIA
genetic structures
Visual Acuity
lcsh:Medicine
law.invention
0302 clinical medicine
CHILDREN AGED 7
Randomized controlled trial
law
OLDER CHILDREN
Clinical endpoint
Medicine
Young adult
PLASTICITY
lcsh:Science
POPULATION
Vision
Binocular

education.field_of_study
Multidisciplinary
Korva-
nenä- ja kurkkutaudit
silmätaudit - Otorhinolaryngology
ophthalmology

Middle Aged
3. Good health
PREVALENCE
Treatment Outcome
Visual Perception
Female
medicine.symptom
medicine.drug
Adult
medicine.medical_specialty
Population
ANISOMETROPIC AMBLYOPIA
Amblyopia
Placebo
Article
CLINICAL-TRIAL
Young Adult
03 medical and health sciences
Fluoxetine
CONTRAST SENSITIVITY
Humans
Learning
3125 Otorhinolaryngology
ophthalmology

education
business.industry
lcsh:R
3112 Neurosciences
RANDOMIZED-TRIAL
eye diseases
Clinical trial
030221 ophthalmology & optometry
lcsh:Q
business
030217 neurology & neurosurgery
Zdroj: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
ISSN: 2045-2322
Popis: Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: −0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (−0.167 logMAR; 95% CI: −0.226 to −0.108; p
Databáze: OpenAIRE