Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia
| Autor: | Johanna Liinamaa, Elina Karvonen, Eero Castrén, Laura Lindberg, J. Matias Palva, Ville Saarela, Marja-Leena Latvala, Henri J. Huttunen, Satu Palva, Hannu Uusitalo, Sigrid Booms |
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| Přispěvatelé: | Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere, Doctoral Programme Brain & Mind, Doctoral Programme in Drug Research, Henri Juhani Huttunen / Principal Investigator, Neuroscience Center, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Matias Palva / Principal Investigator, Silmäklinikka, Clinicum, Eero Castren / Principal Investigator |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics Visual acuity TREAT AMBLYOPIA genetic structures Visual Acuity lcsh:Medicine law.invention 0302 clinical medicine CHILDREN AGED 7 Randomized controlled trial law OLDER CHILDREN Clinical endpoint Medicine Young adult PLASTICITY lcsh:Science POPULATION Vision Binocular education.field_of_study Multidisciplinary Korva- nenä- ja kurkkutaudit silmätaudit - Otorhinolaryngology ophthalmology Middle Aged 3. Good health PREVALENCE Treatment Outcome Visual Perception Female medicine.symptom medicine.drug Adult medicine.medical_specialty Population ANISOMETROPIC AMBLYOPIA Amblyopia Placebo Article CLINICAL-TRIAL Young Adult 03 medical and health sciences Fluoxetine CONTRAST SENSITIVITY Humans Learning 3125 Otorhinolaryngology ophthalmology education business.industry lcsh:R 3112 Neurosciences RANDOMIZED-TRIAL eye diseases Clinical trial 030221 ophthalmology & optometry lcsh:Q business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: −0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (−0.167 logMAR; 95% CI: −0.226 to −0.108; p |
| Databáze: | OpenAIRE |
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