Synthesis of the growth hormone-regulated rat liver anti-protease GHR-P63 is inhibited by acute inflammation
| Autor: | Alphonse Le Cam, Ginette Le Cam |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Turpentine Biophysics Inflammation Growth hormone receptor Biology (Rat) In Vitro Techniques Growth hormone Biochemistry Structural Biology Internal medicine Genetics medicine Protein biosynthesis Animals Hepatocyte RNA Messenger Molecular Biology Serpins integumentary system Acute-phase protein Translation (biology) Cell Biology In vitro Rats stomatognathic diseases Anti-protease Kinetics Endocrinology medicine.anatomical_structure Liver Growth Hormone Protein Biosynthesis Acute Disease sense organs medicine.symptom Protein Processing Post-Translational hormones hormone substitutes and hormone antagonists Acute-Phase Proteins |
| Zdroj: | FEBS letters. 210(1) |
| ISSN: | 0014-5793 |
| Popis: | Synthesis of the growth hormone-regulated anti-protease GHR-P63 by rat hepatocytes was strongly reduced during acute inflammation. This decrease was detected 8 h after the onset of inflammation and reached a maximum after 24 h. A decrease in the GHR-P63 mRNA level measured by in vitro translation and by hybridization mainly accounted for the alteration of GHR-P63 synthesis. Besides this major pretranslational mechanism, inflammation also interfered with GHR-P63 synthesis at a posttranslational level. This was indicated by the production of abnormal immunoprecipitable species at early stages of the acute-phase response. |
| Databáze: | OpenAIRE |
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