Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats
| Autor: | Odukoya S. Ayodeji, Saka O. Stephen, Komolafe O. Aderibigbe, Ayoola I. Olushola |
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| Rok vydání: | 2017 |
| Předmět: |
Persea
Heart Ventricles Sodium Potassium Herb-Drug Interactions chemistry.chemical_element Salt (chemistry) 030204 cardiovascular system & hematology Nitric Oxide Protective Agents Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lactate dehydrogenase Botany medicine Animals Rats Wistar Sodium Chloride Dietary Aqueous extract chemistry.chemical_classification Chromatography L-Lactate Dehydrogenase potassium ion biology Plant Extracts Myocardium lactate dehydrogenase Original Articles sodium ion biology.organism_classification Rats high salt–fed rat medicine.anatomical_structure chemistry Ventricle Persea americana 030217 neurology & neurosurgery Phytotherapy |
| Zdroj: | Journal of Evidence-based Complementary & Alternative Medicine |
| ISSN: | 2156-5899 2156-5872 |
| DOI: | 10.1177/2156587217733884 |
| Popis: | Background. The cardioprotective effects of Persea americana extract was investigated on biochemical activities of high salt–fed adult Wistar rats in this study. Method. Forty healthy Wistar rats of both sexes weighing 120 to 150 g were randomly assigned into 8 groups of 5 rats each (groups A, B, C, D, E, F, G, and H). Rats in groups A, F, G, and H were fed with standard laboratory pellets, while groups B, C, D, and E were fed on the high-salt diet for 4 weeks. Concomitantly, daily administration of 50, 100, and 150 mg/kg of the P americana extract were given orally to groups C and F, D and G, and E and H, respectively, while rats in groups A and B were administered distilled water. Blood samples were taken by cardiac puncture; concentration of sodium ion, potassium ion, nitric oxide, and activity of lactate dehydrogenase were determined. One-way analysis of variance was used to analyze data, followed by Student-Newman-Keuls (SNK) test for multiple comparison. Results. Results revealed that concentration of potassium ion and nitric oxide was significantly lower ( P < .05) in high salt–fed groups. Sodium ion concentration and activity of lactate dehydrogenase were higher in high salt–fed group while P americana prevented biochemical perturbations in other experimental groups. Conclusion. In conclusion, high salt–diet induced biochemical alterations which were significantly protected by oral administration of P americana extract. |
| Databáze: | OpenAIRE |
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