Activation of TRAILDR 5 pathway promotes sensorineural degeneration in the inner ear

Autor: Vítor Yamashiro Rocha Soares, Konstantina M. Stankovic, Shyan-Yuan Kao, Arthur G. Kristiansen
Rok vydání: 2016
Předmět:
Zdroj: Aging Cell
ISSN: 1474-9726
1474-9718
DOI: 10.1111/acel.12437
Popis: Summary Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5‐blocking antibodies.
Databáze: OpenAIRE