Therapeutic and technological potential of 7-chloro-4-phenylselanyl quinoline for the treatment of atopic dermatitis-like skin lesions in mice
| Autor: | Ethel A. Wilhelm, Diego Alves, André R. Fajardo, Guilherme T. Voss, Jaqueline F. de Souza, Renata L. de Oliveira, Cristiane Luchese, Luis Fernando B. Duarte |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science Anti-Inflammatory Agents Bioengineering Inflammation Pharmacology Severity of Illness Index Antioxidants Dexamethasone Dermatitis Atopic Biomaterials Mice 03 medical and health sciences 0302 clinical medicine Spectroscopy Fourier Transform Infrared Dinitrochlorobenzene medicine Animals Sensitization Peroxidase Skin Mice Inbred BALB C Behavior Animal integumentary system biology Therapeutic effect Biofilm Atopic dermatitis Scratching medicine.disease 030104 developmental biology medicine.anatomical_structure Mechanics of Materials 030220 oncology & carcinogenesis Myeloperoxidase Quinolines biology.protein medicine.symptom Reactive Oxygen Species medicine.drug |
| Zdroj: | Materials Science and Engineering: C. 84:90-98 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2017.11.026 |
| Popis: | This study investigated the main effects of the oral treatment with 7-chloro-4-phenylselanyl quinoline (4-PSQ) on symptoms, inflammatory and oxidative parameters in an atopic dermatitis (AD) model in BALB/c mice. In addition, the possibility of antioxidant property of 4-PSQ improves the potential of a biofilm (based on chitosan/poly(vinyl alcohol) (PVA)/ bovine bone powder (BBP)) for the treatment of AD-like skin lesions was evaluated. 2,4-Dinitrochlorobenzene (DNCB) was applied to the dorsal skin on days 1-3 for sensitization. Mice were challenged with DNCB on the ear (on days 14-29) and dorsal skin (on days 14, 17, 20, 23, 26, and 29) and treated with 4-PSQ, dexamethasone, biofilm (biofilm sample without 4-PSQ) or 4-PSQ-loaded biofilms. On the day 30, skin severity scores and scratching behavior were determined. After that, animals were sacrificed, and ears and dorsal skin were removed for determination of inflammatory and oxidative parameters. DNCB induced the skin lesions, scratching behavior and ear swelling, increased myeloperoxidase (MPO) activity (ear and back) and reactive species (RS) levels (back). 4-PSQ, 4-PSQ-loaded biofilms and biofilm treatments ameliorated skin severity scores, scratching behavior and inflammatory response induced by DNCB. 4-PSQ and 4-PSQ-loaded biofilm treatments partially protected against the increase in the RS levels induced by DNCB. Our results revealed that the incorporation of 4-PSQ improved the therapeutic effect of the biofilm. The efficacy of 4-PSQ in treating AD-like lesions was similar or better than dexamethasone. In summary, 4-PSQ has a potential therapeutic advantage in the treatment and management of AD. |
| Databáze: | OpenAIRE |
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