Ki-67, topoisomerase IIα and miR-221 have a limited prostate cancer risk stratification ability on a medium-term follow-up: results of a high-risk radical prostatectomy cohort
| Autor: | Giancarlo Marra, Marco Oderda, Giorgio Calleris, Alessandro Marquis, Federica Peretti, Andrea Zitella, Marco Moschini, Rafael Sanchez-Salas, Robert Jeffrey Karnes, Burkhard Kneitz, Martin Spahn, Donatella Pacchioni, Paolo Gontero |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Translational Andrology and Urology. 11:1271-1281 |
| ISSN: | 2223-4691 2223-4683 |
| DOI: | 10.21037/tau-21-628 |
| Popis: | Currently, no biomarkers are able to differentiate lethal from relatively indolent prostate cancer (PCa) within high-risk diseases. Nonetheless, several molecules are under investigation. Amongst them, topoisomerase-II-alpha (We included 64 consecutive cM0 high-risk PCa [prostate specific antigen (PSA)20 ng/mL or Gleason Score (GS)7 or cT2] undergoing radical prostatectomy (RP). Changes in miR-221 expression and alternative splicing were determined using microarrays. Immunohistochemical determination of Ki67 and TOPIIa were performed using monoclonal antibody MIB-1 and 3F6 respectively. Cox proportional-hazards regression models were used to predict BCR and CR as multivariate analysis. BCR and CR were defined as three consecutive rises in PSA and PSA0.2 ng/mL and histologically-proven local recurrence or imaging positive for distant metastasis respectively.We included 64 men. Mean pre-operative PSA was 26.53 (range, 1.3-135); all GSs were ≥7 and pT was ≥ T3 in 78.13%. Positive margins and lymph-nodes were present in 42.19% and 32.81% respectively. At a mean follow-up of 5.7 years (range, 1.8-12.5), 42.18% experienced BCR (n=27), 29.68% CR (n=19) and 7.81% PcD (n=5). On univariate analysis positive nodes (0.01), seminal vesicle invasion (0.02) and |
| Databáze: | OpenAIRE |
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