Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment
| Autor: | Rémi Cadet, Joelle Henry-Berger, Rachel Guiton, Hanae Pons-Rejraji, Najoua Gharbi, Andrew L. Mellor, Laurent Janny, Aicha Jrad-Lamine, David H. Munn, Joël R. Drevet, Fabrice Saez, Christelle Damon-Soubeyrand, Ayhan Kocer, Robert John Aitken |
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| Přispěvatelé: | Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Chemokine Anatomy and Physiology Cellular differentiation T-Lymphocytes [SDV]Life Sciences [q-bio] Immunology lcsh:Medicine Inflammation Biology Adaptive Immunity Immune tolerance Immunomodulation 03 medical and health sciences Mice 0302 clinical medicine Immune system Internal medicine medicine Animals Indoleamine-Pyrrole 2 3 -Dioxygenase Indoleamine 2 3-dioxygenase lcsh:Science Kynurenine ComputingMilieux_MISCELLANEOUS 030304 developmental biology Epididymis Mice Knockout 0303 health sciences Mice Inbred BALB C 030219 obstetrics & reproductive medicine Multidisciplinary Interleukins lcsh:R Reproductive System Acquired immune system 3. Good health Endocrinology medicine.anatomical_structure biology.protein lcsh:Q medicine.symptom Chemokines Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66494. ⟨10.1371/journal.pone.0066494⟩ PLoS ONE, Vol 8, Iss 6, p e66494 (2013) PLoS ONE, 2013, 8 (6), pp.e66494. ⟨10.1371/journal.pone.0066494⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0066494⟩ |
| Popis: | The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1(-/-) animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed. |
| Databáze: | OpenAIRE |
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