High prevalence of sexually transmitted coinfections among at-risk people living with HIV
| Autor: | Sui-Yuan Chang, Hsin-Yun Sun, Un-In Wu, Yu-Chung Chuang, Yi-Jing Chen, Wen-Chun Liu, Chien-Ching Hung, Tai-Fen Lee, Shan-Chwen Chang, Kuan-Yin Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male HBsAg medicine.medical_specialty Medicine (General) Sexual Behavior Gonorrhea Population HIV Infections Chlamydia trachomatis medicine.disease_cause Men who have sex with men 03 medical and health sciences Sexual and Gender Minorities 0302 clinical medicine R5-920 Internal medicine medicine Prevalence Humans Homosexuality Male Viral hepatitis education education.field_of_study Chlamydia business.industry Coinfection General Medicine Chlamydia Infections medicine.disease Condomless anal intercourse Neisseria gonorrhoeae 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Syphilis Female business |
| Zdroj: | Journal of the Formosan Medical Association, Vol 120, Iss 10, Pp 1876-1883 (2021) |
| ISSN: | 0929-6646 |
| Popis: | Background/Purpose Concurrent sexually transmitted infections (STIs) are not uncommon in at-risk populations, for which control requires integrated testing, treatment and prevention. Methods From May, 2019 to February, 2020, multiplex real-time PCR assays were prospectively performed to detect Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) in the urine and rectal/vaginal swab specimens collected from HIV-positive patients with a history of STIs or symptoms suggestive of STIs. Patients confirmed to have acquired STIs were treated according to treatment guidelines. Results During the study period, 430 participants (99.1% men who have sex with men and median age 37 years) were included. The overall prevalence of CT, NG, and/or TV infection was 30.0%, including 24.7%, 12.1%, and 0.2% for CT, NG, and TV infection, respectively. The factors associated with CT, NG, and/or TV infection were hepatitis B surface antigen (HBsAg) seropositivity (AOR, 2.76; 95% CI, 1.22–6.26), recently acquired hepatitis C virus (HCV) infection (AOR, 5.62; 95% CI, 1.99–15.88), using mobile dating application (AOR, 2.08; 95% CI, 1.13–3.83), and oral sex (AOR, 2.12; 95% CI, 1.04–4.32). The rates of CT, NG, and/or TV infection were 50.0% in participants with recent HCV infection, 44.2% in those with HBsAg positivity, and 35.9% in those with incident syphilis. Among participants completing test-of-cure visits, the microbiological cure rate was 91.7% and 90.0% for chlamydia and gonorrhea, respectively. Conclusion HIV-positive participants had a high prevalence of CT and/or NG, especially those coinfected with viral hepatitis and syphilis. Our results strongly support integrated STI services in the population. |
| Databáze: | OpenAIRE |
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