Thyroid Nodules in Patients with Acromegaly: Frequency According to the ACR TI-RADS Classification and its Relationship with Disease Activity
| Autor: | Mustafa Kulaksizoglu, Mustafa Can, Zeliha Yarar, Feridun Karakurt, Melia Karakose, Hatice Çalişkan Burgucu, Muhammet Kocabaş |
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| Rok vydání: | 2021 |
| Předmět: |
Thyroid nodules
Adult Male medicine.medical_specialty Adolescent Turkey Endocrinology Diabetes and Metabolism Gastroenterology Severity of Illness Index Disease activity Young Adult Endocrinology Internal medicine Acromegaly Internal Medicine medicine Humans In patient Thyroid Nodule Aged business.industry Thyroid Nodule (medicine) General Medicine Middle Aged medicine.disease medicine.anatomical_structure Female medicine.symptom business Body mass index Hormone |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 129(12) |
| ISSN: | 1439-3646 |
| Popis: | Purpose: In our study, we aimed to determine the frequency of thyroid nodules in patients with acromegaly according to the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) classification and its relationship with acromegaly disease activity. Methods: A total of 56 patients with acromegaly and age, sex, and body mass index matched with 56 healthy control subjects were included in our study. Thyroid-stimulating hormone, free thyroxine, and anti-thyroperoxidase antibody levels of patients and control subjects were measured. In addition, patients and healthy controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules and to make ACR TI-RADS classification. Results: Thyroid nodules were present in 31 (55.4%) of 56 patients in the acromegaly group and 20 (35.7%) of 56 subjects in the control group, and the frequency of thyroid nodules was significantly higher in the acromegaly group (p=0.038). The mean number of nodules in the acromegaly group and control group was 1.27±1.43 and 0.48±0.73, respectively, and the mean number of nodules was significantly higher in the acromegaly group (p=0.003). The number of patients with TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules in the acromegaly group was higher than the control group (p=0.026, p=0.049, p=0.007, respectively). No difference was found in terms of cytological findings between those who have undergone FNAB in the acromegaly group and control group. Conclusion: In our study, we found that the frequency of thyroid nodules, the number of thyroid nodules, and the number of TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules increased in patients with acromegaly. There was no significant difference between acromegaly disease activity and thyroid nodule frequency, number of thyroid nodules, and TI-RADS classifications. |
| Databáze: | OpenAIRE |
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