Structure and Stoichiometry of the Ton Molecular Motor
| Autor: | Herve Celia, Susan K. Buchanan, Nicholas Noinaj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular 0301 basic medicine 030106 microbiology energy-transduction Review Catalysis molecular motors Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Bacterial Proteins Escherichia coli Molecular motor Humans Inner membrane Physical and Theoretical Chemistry Electrochemical gradient Molecular Biology lcsh:QH301-705.5 Spectroscopy ton complex Chemistry Escherichia coli Proteins Organic Chemistry Membrane Proteins Proton-Motive Force General Medicine Periplasmic space gram-negative bacteria Computer Science Applications tonb 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Biophysics Ton Protein Multimerization Gram-Negative Bacterial Infections Bacterial outer membrane exbb Stoichiometry exbd |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2, p 375 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | The Ton complex is a molecular motor that uses the proton gradient at the inner membrane of Gram-negative bacteria to generate force and movement, which are transmitted to transporters at the outer membrane, allowing the entry of nutrients into the periplasmic space. Despite decades of investigation and the recent flurry of structures being reported by X-ray crystallography and cryoEM, the mode of action of the Ton molecular motor has remained elusive, and the precise stoichiometry of its subunits is still a matter of debate. This review summarizes the latest findings on the Ton system by presenting the recently reported structures and related reports on the stoichiometry of the fully assembled complex. |
| Databáze: | OpenAIRE |
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