Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease
| Autor: | Jason R. Richardson, Cooper T. Johnson, Melissa K. Edler, Hashim S. Ahmed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
CD36 Antigens Male medicine.medical_specialty Mice 129 Strain CD36 Hippocampus Mice Transgenic Plaque Amyloid Striatum Midbrain 03 medical and health sciences Mice 0302 clinical medicine Alzheimer Disease Internal medicine parasitic diseases Basal ganglia medicine Human Umbilical Vein Endothelial Cells Animals Humans Scavenger receptor Neuroinflammation Cerebral Cortex Sex Characteristics biology General Neuroscience Age Factors hemic and immune systems medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology nervous system biology.protein Female Cerebral amyloid angiopathy 030217 neurology & neurosurgery circulatory and respiratory physiology |
| Zdroj: | The Journal of comparative neurologyREFERENCES. 529(9) |
| ISSN: | 1096-9861 |
| Popis: | Scavenger receptor CD36 contributes significantly to lipid homeostasis, inflammation, and amyloid deposition, while CD36 deficiency is associated with restored cerebrovascular function in an Alzheimer's disease (AD) mouse model. Yet the distribution of CD36 has not been examined in the brain. Here, we characterized CD36 gene and protein expression in the brains of young, middle aged, aged, and elderly male and female C57BL/6J mice. Age-related increases in CD36 mRNA expression were observed in the male hippocampus and female midbrain. Additionally, male mice had greater CD36 mRNA expression than females in the striatum, hippocampus, and midbrain. CD36 protein was primarily expressed intravascularly, and this expression differed by region, age, and sex in the mouse brain. Although male mice brains demonstrated an increase in CD36 protein with age in several cortices, basal ganglia, hippocampus, and midbrain, a decrease with age was observed in female mice in the same regions. These data suggest that distinctive age, region, and sex expression of CD36 in the brain may contribute to Aβ deposition and neuroinflammation in AD. |
| Databáze: | OpenAIRE |
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