Antibody, complement and accommodation in ABO-incompatible transplants
| Autor: | Robert A. Montgomery, Karen E. King, William M. Baldwin, Daniel S. Warren, Sally A. Campbell-Lee, Milagros Samaniego-Picota |
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| Rok vydání: | 2004 |
| Předmět: |
biology
Immunology food and beverages Endothelial Cells Inflammation Complement System Proteins Adaptation Physiological Antibodies ABO Blood-Group System Transplantation Von Willebrand factor Antigen Downregulation and upregulation ABO blood group system Blood Group Incompatibility biology.protein medicine Immunology and Allergy iC3b Animals Humans Transplantation Homologous medicine.symptom Antibody |
| Zdroj: | Current opinion in immunology. 16(5) |
| ISSN: | 0952-7915 |
| Popis: | Many facets of accommodation have been explored since this process was first observed in ABO-incompatible renal allografts over 17 years ago. Intriguing new pieces of the puzzle have emerged to be fitted into the picture in several places. For example, vascular endothelial cells can be stimulated to secrete substantial amounts of blood group A and B antigens linked to von Willebrand factor; the antibody response to A and B antigens stimulated by ABO-incompatible renal allografts can show epitope spreading; complement can inhibit inflammation through actions of some complement split products, particularly iC3b and C3a; endothelial cells can upregulate various cytoprotective mechanisms; and clinically, new protocols for achieving accommodation have been implemented with improved results. |
| Databáze: | OpenAIRE |
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