Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer
| Autor: | Bin Shao, Guohong Song, Fengling Wan, Xiaoran Liu, Zewen Wei, Xu Liang, Guo-bing Xu, Yanlian Yang, Ruyan Zhang, Huiping Li, Hope S. Rugo, Zhi-yuan Hu, Hanfang Jiang, Ying Yan, Weiyao Kong, Ran Ran |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Cell Disease circulating tumor cell Natural killer cell immunology 03 medical and health sciences Breast cancer 0302 clinical medicine Circulating tumor cell Clinical Research Internal medicine medicine Oncology & Carcinogenesis Prospective cohort study neoplasms Triple-negative breast cancer Cancer nanotechnology business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Original Article business |
| Zdroj: | Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, vol 30, iss 3 |
| ISSN: | 1000-9604 |
| DOI: | 10.21147/j.issn.1000-9604.2018.03.04 |
| Popis: | Objective Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis. Circulating tumor cells (CTCs) are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival (PFS) is controversial. We aim to verify their predictive value in TNBC. Methods In present prospective cohort study, we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC (taken at inclusion in this study) and analyzed correlations between CTC numbers and outcomes and other clinical parameters. Results Median PFS was 6.0 (range: 1.0-25.0) months for the entire cohort, in whom we found no correlations between baseline CTC status and initial tumor stage (P=0.167), tumor grade (P=0.783) or histological type (P=0.084). However, among those getting first-line treatment, baseline CTC status was positively correlated with ratio of peripheral natural killer (NK) cells (P=0.032), presence of lung metastasis (P=0.034) and number of visceral metastatic site (P=0.037). Baseline CTC status was predictive for PFS in first-line TNBC (P=0.033), but not for the cohort as a whole (P=0.118). This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration (P=0.049). Conclusions Baseline CTC status was predictive of lung metastasis, peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment. We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. |
| Databáze: | OpenAIRE |
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