Solid organ transplantation worsens the prognosis of patients with cutaneous squamous cell carcinoma of the head and neck region-Comparison between solid organ transplant recipients and immunocompetent patients
| Autor: | Aron Popovtzer, Samih Badir, Dean Ad-El, Gideon Bachar, Thomas Shpitzer, Zvi Segal, Aviram Mizrachi, Amit Ritter, Muhammad Azmi Mansour |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cutaneous squamous cell carcinoma Skin Neoplasms Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Head and neck Lymph node Retrospective Studies business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Organ Transplantation medicine.disease Prognosis Transplantation medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Solid organ Skin cancer Neoplasm Recurrence Local business Solid organ transplantation |
| Zdroj: | HeadneckREFERENCES. 43(3) |
| ISSN: | 1097-0347 |
| Popis: | Background Cutaneous squamous cell carcinoma of the head and neck (CSCC-HN) appears to behave more aggressively in immunosuppressed patients. We aimed to investigate this hypothesis by comparing solid organ transplant recipients (SOTR) with CSCC-HN to immunocompetent patients. Methods A retrospective comparative study was conducted for SOTR and immunocompetent patients who were treated for CSCC-HN. Results A total of 177 SOTR and 157 immunocompetent patients with CSCC-HN were included. Lymph node metastases were more common in the SOTR group (9% vs 3%), and distant metastases occurred only in SOTR (3% of patients). SOTR had a higher rate of recurrences (19% vs 10%), which were mostly regional (7%) and distant (3%). The 2-year disease-specific survival of SOTR was lower (93% vs 100%). Conclusions SOTR with CSCC-HN has significantly worse outcomes compared to immunocompetent patients. Solid-organ transplantation should be regarded as a negative prognostic factor in patients with CSCC-HN. |
| Databáze: | OpenAIRE |
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