Dynamic correlation of apoptosis and immune activation during treatment of HIV infection
| Autor: | Jonathan B. Angel, David H. Lynch, Barbara N. Phenix, Donald William Cameron, D Ashby, Ashok Kumar, Jürg Tschopp, Stephen Kravcik, Karl Parato, Andrew D. Badley |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Adolescent Anti-HIV Agents CD3 T-Lymphocytes CASP8 and FADD-Like Apoptosis Regulating Protein Apoptosis HIV Infections CD38 Pathogenesis Immune system Cytotoxic T cell Medicine Humans fas Receptor Molecular Biology Saquinavir Nelfinavir biology business.industry Intracellular Signaling Peptides and Proteins Nucleosides Cell Biology HIV Protease Inhibitors Middle Aged Fas receptor Immunology biology.protein Reverse Transcriptase Inhibitors Drug Therapy Combination business Carrier Proteins CD8 |
| Zdroj: | Cell death and differentiation. 6(5) |
| ISSN: | 1350-9047 |
| Popis: | T cells from HIV infected patients undergo spontaneous apoptosis at a faster rate than those from uninfected patients, are abnormally susceptible to activation induced cell death (AICD), and undergo increased apoptosis in response to Fas receptor ligation. These observations have led to the hypothesis CD4 T cell apoptosis may be a mechanism of CD4 T cell depletion and the pathogenesis of AIDS. Successful treatment of HIV infected patients is accompanied by quantitative and qualitative improvements in immune function reflecting at least partial reversibility of the underlying pathogenesis of HIV. In this report we correlate improvements in markers of immune function with a decrease in apoptosis, and changes in its regulation. Therapy with nelfinavir plus saquinavir in combination with two nucleoside analogue inhibitors of reverse transcriptase dramatically reduces plasma viremia and increases CD4 T cell counts. Coincident with these improvements, CD38 and HLA-DR coexpression on both CD4 and CD8 T cells decrease, and CD45RA and CD62L coexpression increase. Furthermore, spontaneous apoptosis decreases in both CD4 and CD8 T cells (CD4 apoptosis 17.4 vs 2.6%, P=0.005; CD8 apoptosis 15.0 vs 1.0%, P |
| Databáze: | OpenAIRE |
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