Measuring the mechanical efficiency of a working cardiac muscle sample at body temperature using a flow-through calorimeter
| Autor: | Callum M. Johnston, Andrew J. Taberner, June-Chiew Han, Denis S. Loiselle, Bryan P. Ruddy, Poul M. F. Nielsen, Toan Pham |
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| Rok vydání: | 2015 |
| Předmět: |
Hot Temperature
Temperature control Work output Materials science Myocardium Sample (material) Flow (psychology) Temperature Cardiac muscle Thermodynamics Calorimetry Body Temperature Calorimeter Stress (mechanics) Thermoelectric generator medicine.anatomical_structure medicine Body Temperature Regulation Biomedical engineering |
| Zdroj: | EMBC |
| DOI: | 10.1109/embc.2015.7320240 |
| Popis: | We have developed a new `work-loop calorimeter' that is capable of measuring, simultaneously, the work-done and heat production of isolated cardiac muscle samples at body temperature. Through the innovative use of thermoelectric modules as temperature sensors, the development of a low-noise fluid-flow system, and implementation of precise temperature control, the heat resolution of this device is 10 nW, an improvement by a factor of ten over previous designs. These advances have allowed us to conduct the first flow-through measurements of work output and heat dissipation from cardiac tissue at body temperature. The mechanical efficiency is found to vary with peak stress, and reaches a peak value of approximately 15 %, a figure similar to that observed in cardiac muscle at lower temperatures. |
| Databáze: | OpenAIRE |
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