Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
| Autor: | Lidia Glodzik-Sobanska, Leslie A. Saint Louis, Susan De Santi, Kaj Blennow, Ray Zinkowski, Remigiusz Switalski, Anders Wallin, Sindre Rolstad, Miroslaw Brys, Elizabeth Pirraglia, Lisa Mosconi, Domenico Praticò, Kenneth Rich, Pankaj D. Mehta, Mony J. de Leon |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Aging medicine.medical_specialty Longitudinal study Pathology Isoprostane Amyloid beta tau Proteins Isoprostanes Gastroenterology Article Cohort Studies Central nervous system disease chemistry.chemical_compound Degenerative disease Cerebrospinal fluid Alzheimer Disease Predictive Value of Tests Internal medicine mental disorders medicine Humans Longitudinal Studies Aged Aged 80 and over Amyloid beta-Peptides biology General Neuroscience Middle Aged Prognosis medicine.disease Peptide Fragments Early Diagnosis chemistry Predictive value of tests Disease Progression biology.protein Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Cognition Disorders Psychology Biomarkers Developmental Biology |
| Zdroj: | Neurobiology of Aging. 30:682-690 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2007.08.010 |
| Popis: | Objectives—To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from Mild Cognitive Impairment (MCI) to Alzheimer’s disease (AD) Methods—A baseline and 2-year follow-up clinical and CSF study of 86 subjects, including 22 MCI patients that declined to AD (MCI-AD), 43 MCI that did not deteriorate (MCI-MCI) and 21 controls (NL-NL). All subjects were studied for total and phosphorylated tau (T-tau, P-tau231), amyloid beta (Aβ) Aβ42/Aβ40 ratio, isoprostane (IP) as well as P-tau231/Aβ42/40 and T-tau/Aβ42/40 ratios. Results—At baseline and at follow-up MCI-AD showed higher levels P-tau231, T-tau, IP, Ptau231/Aβ42/40 and T-tau/Aβ42/40 ratios and lower Aβ42/Aβ40 than MCI-MCI or NL-NL. Baseline P-tau231 best predicted MCI-AD (80%, p |
| Databáze: | OpenAIRE |
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