Ultrastructural study of hepatic effects of a contraceptive steroid in baboon
| Autor: | Lee S. Chai, Avery A. Sandberg, James G. Colson, Rashad Y. Kirdani |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Biopsy Population Administration Oral Golgi Apparatus Cytoplasmic Granules Endoplasmic Reticulum chemistry.chemical_compound Internal medicine biology.animal Parenchyma medicine Animals education education.field_of_study Glycogen biology business.industry Endoplasmic reticulum Obstetrics and Gynecology Histology Liver Glycogen Microscopy Electron Endocrinology Liver Reproductive Medicine chemistry Ultrastructure Hepatic stellate cell Norethindrone business Papio Baboon |
| Zdroj: | Contraception. 10:79-93 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(74)90135-8 |
| Popis: | Observations were made of the chronic administration of norethindron e orally to 2 male baboons (Papio anubis), 1 mg/day daily for 1 month and then 5 mg/day for 5 months. A third animal was given the biscuits used for administration but without the drug. Liver biopsies were made 1 week prior to treatment, each month during treatment, and for 2 months following termination of treatment. Under electron microscopic magnification of 3000-12000 diameters, ultrastructural observations revealed dilatation and vesiculation of the endoplasmic reticulum as well as of the Golgi complexes. Cells with depleted glycogen granules w ere frequent and usually seen next to cells with glycogen. Accumulation of increased numbers and sizes of electron-dense microbodies was observed as treatment continued. Cells with large vacuolated inclusion bodies were always associated with anomalous bile canaliculi. Endothelial sinusoids included both macrophages and numerous electron-dense microbodies, especially in the later stages of treatment. A collagen substance appeared to have infiltrated the sinusoids of some of the parenchymal cells. When therapy was terminated the ultrastructure of the biopsy material showed progressive regeneration toward normal morphology. At the end of 2 months this structure was similar to control materials. Hepatic changes observed in this study are similar to those reported by others as occurring in women using oral contraceptives. The hepatocellurlar changes were temporary and reversible. |
| Databáze: | OpenAIRE |
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