Common allergies do not influence the prevalence of cutaneous hypersensitivity reactions to antiepileptic drugs
| Autor: | Grzegorz Porebski, Wojciech Turaj, Magdalena Bosak, Agnieszka Slowik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Allergy medicine.medical_specialty Adolescent Lamotrigine Cohort Studies 03 medical and health sciences Epilepsy 0302 clinical medicine Prevalence Respiratory Hypersensitivity Medicine Humans Adverse effect Oxcarbazepine Asthma business.industry Atopic dermatitis Exanthema medicine.disease Rash Dermatology 030228 respiratory system Neurology Anticonvulsants Female Neurology (clinical) Drug Eruptions medicine.symptom business 030217 neurology & neurosurgery Food Hypersensitivity medicine.drug |
| Popis: | Objective The aim of the study was to establish whether the presence of common allergies increases the risk of drug-related hypersensitivity reactions among patients with epilepsy treated with antiepileptic drugs (AEDs). Methods We studied 753 patients with epilepsy seen in tertiary outpatient epilepsy clinic. We obtained data related to epilepsy type, past and ongoing treatment with AEDs, occurrence of maculopapular exanthema or more serious cutaneous adverse reactions (Stevens-Johnson syndrome − SJS) and their characteristics. We noted an occurrence of allergic reactions unrelated to treatment with AED, including rash unrelated to AED, bronchial asthma, persistent or seasonal allergic rhinitis, atopic dermatitis, rash after specific food and other allergic reactions. Results There were 61 cases of AED-related cutaneous hypersensitivity reaction (including 3 cases of SJS) noted in association with 2319 exposures to AEDs (2.63%) among 55 out of 753 patients (7.3%). Cutaneous hypersensitivity reaction to AED was most commonly noted after lamotrigine (12.1%), carbamazepine (5.4%) and oxcarbazepine (4.1%). Prevalence of allergic reactions unrelated to AED was similar between patients with and without AED-related cutaneous hypersensitivity reaction (rash unrelated to AED: 16.4% vs. 10.2%; bronchial asthma: 1.8% vs. 0.1%; persistent allergic rhinitis: 7.3% vs. 10.2%; seasonal allergic rhinitis: 7.3% vs. 11.7%; atopic dermatitis: 0 vs. 0.7%; rash after specific food: 5.4% vs. 6.4%; other allergic reactions: 5.4% vs. 5.2%, respectively; P > 0.1 for each difference). Conclusions Presence of common allergies is not a significant risk factor for AED-related cutaneous hypersensitivity reaction among patients with epilepsy. |
| Databáze: | OpenAIRE |
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