Aluminum chloride stimulates the release of endogenous glutamate, taurine and adenosine from cultured rat cortical astrocytes
| Autor: | Jan Albrecht, Michael D. Norenberg, Martha L. Simmons, Gary R. Dutton |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Taurine Adenosine Glutamic Acid Biology chemistry.chemical_compound Chlorides Glutamates Internal medicine medicine Aluminum Chloride Animals Aluminum Compounds Cells Cultured Cerebral Cortex General Neuroscience Osmolar Concentration Glutamate receptor Rats medicine.anatomical_structure Endocrinology Biochemistry chemistry Cerebral cortex Astrocytes Liberation Neuroglia Nucleoside Aluminum Astrocyte medicine.drug |
| Zdroj: | Neuroscience Letters. 127:105-107 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(91)90905-9 |
| Popis: | Primary astrocyte cultures derived from neonatal rat cerebral cortex were treated for 5 min with 0.5 mM or 5.0 mM AlCl3, and the incubation medium was analyzed by HPLC for the content of released glutamate (Glu), taurine (Tau), serine (Ser) and the nucleoside adenosine (Ade). At 0.5 mM, AlCl3 stimulated Tau release to about 170% of basal levels, but did not affect the release of the other compounds. Treatment with 5.0 mM AlCl3 enhanced the release of Tau, Glu and Ade, to 800%, 1000% and 250%, respectively, but decreased the release of Ser to 70% compared to basal levels. The enhanced release of these neuroactive compounds from astrocytes may contribute to changes in neural transmission known to accompany exposure to aluminum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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