An Overview of Helicobacter pylori VacA Toxin Biology
| Autor: | Mark S. McClain, Timothy L. Cover, Rhonda R. Caston, Nora J. Foegeding, Melanie D. Ohi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell type vacuolating toxin Transcription Genetic Protein Conformation Health Toxicology and Mutagenesis lcsh:Medicine Vacuole Review Toxicology medicine.disease_cause Ion Channels Microbiology 03 medical and health sciences Immune system Bacterial Proteins medicine Animals Humans bacterial toxins biology Helicobacter pylori Toxin Stomach gastric cancer autotransporter lcsh:R biology.organism_classification bacterial infections and mycoses In vitro digestive system diseases 3. Good health type V secretion 030104 developmental biology medicine.anatomical_structure bacteria Intracellular |
| Zdroj: | Toxins, Vol 8, Iss 6, p 173 (2016) Toxins |
| ISSN: | 2072-6651 |
| Popis: | The VacA toxin secreted by Helicobacter pylori enhances the ability of the bacteria to colonize the stomach and contributes to the pathogenesis of gastric adenocarcinoma and peptic ulcer disease. The amino acid sequence and structure of VacA are unrelated to corresponding features of other known bacterial toxins. VacA is classified as a pore-forming toxin, and many of its effects on host cells are attributed to formation of channels in intracellular sites. The most extensively studied VacA activity is its capacity to stimulate vacuole formation, but the toxin has many additional effects on host cells. Multiple cell types are susceptible to VacA, including gastric epithelial cells, parietal cells, T cells, and other types of immune cells. This review focuses on the wide range of VacA actions that are detectable in vitro, as well as actions of VacA in vivo that are relevant for H. pylori colonization of the stomach and development of gastric disease. |
| Databáze: | OpenAIRE |
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