Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic - a randomized, double-blind controlled study
| Autor: | Jörg Siebert, Luc Téot, Wolfgang Vanscheidt, Keith G Harding |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Pyridines medicine.drug_class Occlusive Dressings Dermatology Phenoxyethanol Varicose Ulcer law.invention chemistry.chemical_compound Double-Blind Method Antiseptic Randomized controlled trial law Humans Medicine Adverse effect Aged Retrospective Studies Wound Healing business.industry Retrospective cohort study Original Articles Surgery Occlusive dressing Treatment Outcome chemistry Histocompatibility Anesthesia Chronic Disease Anti-Infective Agents Local Female Imines business Wound healing Follow-Up Studies Octenidine dihydrochloride |
| Zdroj: | Int Wound J |
| ISSN: | 1742-4801 |
| DOI: | 10.1111/j.1742-481x.2011.00886.x |
| Popis: | The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double‐blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound‐healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·952), without being influenced by wound size or duration of the target ulcer (P‐values: 0·947/0·978). In patients treated with OHP, fewer adverse events (AEs) were observed compared with the Ringer group (17% versus 29% of patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers. |
| Databáze: | OpenAIRE |
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