Saccharomyces boulardiiStimulates Intestinal Immunoglobulin A Immune Response toClostridium difficileToxin A in Mice
| Autor: | Pierre Michetti, Michel Warny, Samer Aboudola, Ciaran P. Kelly, J. Thomas Lamont, C Pothoulakis, Amir A. Qamar |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Diarrhea
Immunoglobulin A Bacterial Toxins Immunology Clostridium difficile toxin A Microbiology Clostridium Difficile Colitis Enterotoxins Mice Saccharomyces Intestinal mucosa medicine Animals Intestinal Mucosa Colitis Mice Inbred BALB C biology Toxoid Clostridium difficile medicine.disease biology.organism_classification Infectious Diseases Microbial Immunity and Vaccines Immunoglobulin A Secretory biology.protein Immunization Parasitology Antitoxins Saccharomyces boulardii |
| Zdroj: | Infection and Immunity. 69:2762-2765 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Saccharomyces boulardiiis a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrentClostridium difficilecolitis. The administration ofC. difficiletoxoid A by gavage toS. boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P= 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P< 0.001). Enhancing host intestinal immune responses may be an important mechanism forS. boulardii-mediated protection against diarrheal illnesses. |
| Databáze: | OpenAIRE |
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