Iron deficiency and anemia of chronic disease in elderly women: a discriminant-analysis approach for differentiation
| Autor: | E. E. Morse, Robert B. Bendel, N. R. Haley, Carol J. Lammi-Keefe, Namanjeet Ahluwalia, J. L. Beard |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Anemia Iron Medicine (miscellaneous) Transferrin receptor Blood Sedimentation Gastroenterology Hemoglobins Discriminant function analysis Internal medicine Receptors Transferrin medicine Humans Geriatric Assessment Aged Inflammation Nutrition and Dietetics Anemia Iron-Deficiency medicine.diagnostic_test business.industry Discriminant Analysis Iron deficiency medicine.disease Hematocrit Iron-deficiency anemia Erythrocyte sedimentation rate Chronic Disease Ferritins Immunology Female Hemoglobin business Anemia of chronic disease |
| Zdroj: | The American Journal of Clinical Nutrition. 61:590-596 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/61.3.590 |
| Popis: | To differentiate iron-deficiency anemia and anemia associated with chronic inflammatory diseases in elderly women, subsets of laboratory, dietary, and functional assessment variables were obtained by using discriminant analysis. Fifty-one subjects (70-79 y of age) were classified into one of four groups on the basis of the presence of iron deficiency and chronic inflammatory disease. Iron deficiency was defined on the basis of a significant response in hemoglobin concentration after iron supplementation. The discriminating subset of laboratory tests consisted of measures for serum ferritin, plasma transferrin receptors, and erythrocyte sedimentation rate. The discriminant function classified subjects into iron-deficient, anemia of chronic disease, or a category in which the two coexist, with an error rate of 18.6%. The addition of other variables (dietary iron and functional assessment information) did not appreciably improve the classification. The results of these three key laboratory tests may help to identify functional iron deficiency in the presence of chronic inflammation. |
| Databáze: | OpenAIRE |
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