Parameters and pitfalls to consider in the conduct of food additive research, Carrageenan as a case study
| Autor: | Myra L. Weiner |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
food.ingredient NCM460 cells Carrageenan Body weight Toxicology Risk Assessment 03 medical and health sciences chemistry.chemical_compound food Toxicity Tests Animals Humans Palatability Food science Strong binding Food additive Chemistry Cell model Vehicles General Medicine Food Analysis Molecular Weight 030104 developmental biology Infant formula Consumer Product Safety Food Additives Test methods Food Science |
| Zdroj: | Food and Chemical Toxicology. 87:31-44 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2015.11.014 |
| Popis: | This paper provides guidance on the conduct of new in vivo and in vitro studies on high molecular weight food additives, with carrageenan, the widely used food additive, as a case study. It is important to understand the physical/chemical properties and to verify the identity/purity, molecular weight and homogeneity/stability of the additive in the vehicle for oral delivery. The strong binding of CGN to protein in rodent chow or infant formula results in no gastrointestinal tract exposure to free CGN. It is recommended that doses of high Mw non-caloric, non-nutritive additives not exceed 5% by weight of total solid diet to avoid potential nutritional effects. Addition of some high Mw additives at high concentrations to liquid nutritional supplements increases viscosity and may affect palatability, caloric intake and body weight gain. In in vitro studies, the use of well-characterized, relevant cell types and the appropriate composition of the culture media are necessary for proper conduct and interpretation. CGN is bound to media protein and not freely accessible to cells in vitro. Interpretation of new studies on food additives should consider the interaction of food additives with the vehicle components and the appropriateness of the animal or cell model and dose–response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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