Glaucoma in a New Zealand White Rabbit Fed High-cholesterol Diet
| Autor: | Nobuo Takasu, Koichi Masuno, Kae Fujisawa, Emi Kashiwagi, Mikinori Torii, Shuuichi Matsushima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology genetic structures New Zealand white rabbit Glaucoma Case Report Toxicology Pathology and Forensic Medicine Lesion Ciliary body Ophthalmology medicine spontaneous biology business.industry biology.organism_classification medicine.disease eye diseases Sclera medicine.anatomical_structure glaucoma Histopathology Choroid sense organs medicine.symptom business Optic disc |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| Popis: | Goniodysgenesis, malformation of the filtration angle, was observed in a New Zealand white rabbit supplied with 100 g/day rabbit chow containing 0.2% cholesterol for 10 months. Histopathology revealed cupping of the optic disc, atrophy of the retina and hyalinization of the ciliary body in the bilateral eyeballs. These findings corresponded with histopathological features caused by glaucoma. On the basis of these findings, we diagnosed this lesion as glaucoma, and classified it as primary glaucoma because of the presence of developmental defects of the filtration angle. In this case, hypercholesterolemia-induced changes, such as aggregation of lipid-laden macrophages and cholesterin clefts in the sclera or choroid, might cause deterioration of the lesions in glaucoma. |
| Databáze: | OpenAIRE |
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