Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status
Autor: | Milan Vošmik, Jana Nekvindová, Ales Ryska, Helena Dolezalova, Jan Laco, Folakemi Sobande, Hana Vošmiková, Eva Cermakova, Petr Celakovsky, Luboš Tuček, V. Nováková, T Neskudlova, M Hácová |
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Rok vydání: | 2012 |
Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Polymerase Chain Reaction Immunoenzyme Techniques Risk Factors P16 ink4a Internal medicine medicine Carcinoma Humans In patient Papillomaviridae Survival rate Cyclin-Dependent Kinase Inhibitor p16 Hpv status Aged Neoplasm Staging Aged 80 and over Surrogate endpoint business.industry Papillomavirus Infections Smoking Case-control study Middle Aged Prognosis medicine.disease Survival Rate Oropharyngeal Neoplasms stomatognathic diseases Case-Control Studies DNA Viral Carcinoma Squamous Cell Immunohistochemistry Female Mouth Neoplasms Neoplasm Recurrence Local business |
Zdroj: | Neoplasma. 59:398-408 |
ISSN: | 1338-4317 |
Popis: | The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) (p16) expression, and human papillomavirus (HPV) status.The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers and the other half were gender-, age- and tumor localization-matched smokers. p16 expression was detected in 17/48 (35 %) OSCCs and in 36/44 (82 %) OPSCCs and HPV DNA was present in 7/48 (15 %) OSCCs and in 35/44 (80 %) OPSCCs. The sensitivity and specificity of p16 expression for HPV DNA presence were 0.74 and 0.88, respectively. The OPSCCs were more frequently basaloid (p0.001) while the OSCCs were more frequently conventional (p0.000001). The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).The HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p0.000001 in all 4 parameters). The HPV-negative tumors were more frequently localized in oral cavity (p0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003). There was no significant difference with regard to smoking history (p0.05). The survival of patients with HPV-positive tumors was significantly longer (median 112 months; 95% CI 54 - 112 months) than that of patients with HPV-negative tumors (median 17 months; 95% CI 12 - 39 months) (p0.001). The HPV status of OSCC/OPSCC is an important biological and prognostic parameter and should be examined in all cases, using PCR or immunohistochemical detection of surrogate marker p16. Smoking itself does not seem to be an important prognostic factor. |
Databáze: | OpenAIRE |
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