The associations among vitamin D deficiency, C-reactive protein, and depressive symptoms
| Autor: | Chan-Hyun Jung, Eun-Jin Kim, Se-Won Lim, Hyungjun Kim, Young-Chul Shin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Logistic regression Gastroenterology vitamin D deficiency Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Republic of Korea medicine Vitamin D and neurology Humans Vitamin D Depression (differential diagnoses) Depressive symptoms Aged biology Depression business.industry C-reactive protein Confounding Odds ratio Middle Aged Vitamin D Deficiency medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology C-Reactive Protein Cross-Sectional Studies Endocrinology biology.protein Female business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychosomatic Research. 90:98-104 |
| ISSN: | 0022-3999 |
| DOI: | 10.1016/j.jpsychores.2016.10.001 |
| Popis: | Objective Vitamin D deficiency has been reported to be associated with depression, but the underlying mechanisms aren't well understood. Our study aims to investigate the associations among serum vitamin D, C-reactive protein (CRP) level, and depressive symptoms. Methods Serum levels of Vitamin D and CRP were measured from 52,228 participants. Depressive symptoms were assessed using a Korean version of the CES-D scale. We used logistic regression to calculate the odds ratio (ORs) of depressive symptoms according to vitamin D and CRP levels. The regressions were adjusted for covariates, and each model was adjusted mutually for vitamin D and CRP levels. Results A significant difference was found in vitamin D status between depressed and non-depressed participants, but CRP status was not significantly different. The OR for the presence of depressive symptoms was significantly increased in participants with vitamin D deficiency after adjusting for potentially confounding factors (Adjusted OR = 1.158, 95% CI = 1.003–1.336, p = 0.046). The OR of depressive symptoms was not significantly increased in individuals with high (3.01-10 mg/L) CRP level compared to individuals with low (≤ 3 mg/L) CRP level (Adjusted OR = 1.004, 95% CI = 0.821–1.227, p = 0.97). There was no significant association between vitamin D and CRP level. Additional adjustment for serum CRP level did not weaken the resulting association between vitamin D deficiency and the presence of depressive symptoms. Conclusion Vitamin D deficiency was associated with depressive symptoms, but elevated serum CRP level was not. The results indicate that CRP level does not account for the association between vitamin D deficiency and the presence of depressive symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect