Different expression of proteins in platelets from aspirin-resistant and aspirin-sensitive patients
| Autor: | Antonio Fernández-Ortiz, Luis Azcona, Esther Bernardo, Petra J. Mateos-Cáceres, Carlos Macaya, Antonio López-Farré, Estela Mahillo, Javier Modrego |
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| Rok vydání: | 2010 |
| Předmět: |
Blood Platelets
Male Proteomics medicine.medical_specialty Platelet Function Tests Cell Survival Blotting Western Drug Resistance Myocardial Ischemia Inflammation Biology medicine.disease_cause Peptide Mapping Mass Spectrometry Internal medicine medicine Humans Electrophoresis Gel Two-Dimensional Platelet Protein disulfide-isomerase Aged Aspirin Blood Proteins Hematology Middle Aged Blood proteins Isotype Cytoskeletal Proteins Oxidative Stress Treatment Outcome Endocrinology Biochemistry Platelet aggregation inhibitor Female Inflammation Mediators medicine.symptom Energy Metabolism Gelsolin Biomarkers Platelet Aggregation Inhibitors Oxidative stress |
| Zdroj: | Thrombosis and Haemostasis. 103:160-170 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th09-05-0290 |
| Popis: | SummaryThe aim of the present study was to analyse differences in the protein expression profile between platelets from aspirin (ASA)-resistant patients and ASA-sensitive patients. We analysed platelets from 51 clinically stable coronary ischaemic patients taking ASA (100 mg/day) divided into ASA-resistant (n=25) and ASA-sensitive (n=26) based on a platelet functionality test (PFA-100). Proteins associated with cytoskeleton, energetic metabolism, oxidative stress, inflammation and cell survival were analysed by two-dimensional electrophoresis and mass spectrometry. The expression of two gelsolin precursor isotypes and one F-acting capping protein isotype was decreased in ASA-resistant platelets (p |
| Databáze: | OpenAIRE |
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