Bioactive secondary metabolites from Schizogyne sericea (Asteraceae) endemic to Canary Islands
| Autor: | Luana Quassinti, Christian Zorzetto, Luca Agostino Vitali, Romilde Iannarelli, R. M. Rabanal, Fabrizio Papa, Armandodoriano Bianco, Filippo Maggi, Alessandro Venditti, Giulio Lupidi, Sauro Vittori, Silvia Damiano, Camilla Muscolo, Massimo Bramucci, Dezemona Petrelli, C.C. Sánchez-Mateo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Antifungal Agents
DPPH Secondary Metabolism Bioengineering Microbial Sensitivity Tests Asteraceae 01 natural sciences Biochemistry Antioxidants law.invention chemistry.chemical_compound Structure-Activity Relationship Phenols law Cell Line Tumor Candida albicans Oils Volatile Humans Agar diffusion test Molecular Biology Thymol Essential oil Cell Proliferation ABTS Traditional medicine Bacteria Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry General Chemistry General Medicine Antineoplastic Agents Phytogenic 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Caffeoylquinic acid chemistry Phytochemical Spain Molecular Medicine Trolox |
| Popis: | Schizogyne sericea (Asteraceae) is a halophytic shrub endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory, and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the EtOH extract, eight compounds were isolated and structurally elucidated. Essential oil, polar fractions, and isolates (2), (4), and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, and HCT116) by MTT assay, for antioxidant potential by DPPH, ABTS, and FRAP assays, and for antimicrobial activity by the agar disk diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, and in some cases, higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and caffeoylquinic acid derivatives 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role. |
| Databáze: | OpenAIRE |
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