Measurement of Liver Iron Concentration by MRI Is Reproducible
| Autor: | Emma Salvador, Ohiana Vicente, Xabier Arozena, Ana Belén Asensio, Lourdes Jauregui, Agustin Castiella, José María Alústiza, Aranzazu Moyua, Nerea García, Pablo Aldazabal, Manuel San Vicente, Jesus M. Banales, Alfonso Casado, A. Garrido, Jose I. Emparanza, Miguel Zarco |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Liver Iron Concentration
Materials science Article Subject General Immunology and Microbiology medicine.diagnostic_test Phantoms Imaging business.industry Iron Coefficient of variation lcsh:R Reproducibility of Results lcsh:Medicine Magnetic resonance imaging General Medicine equipment and supplies Magnetic Resonance Imaging General Biochemistry Genetics and Molecular Biology Imaging phantom Radiography Liver medicine Humans Nuclear medicine business Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose. The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients.Materials and Methods. A phantom reproducing the liver/muscle ratios of two patients with intermediate and high iron overload. Nine patients with different levels of iron overload were studied in 4 multivendor devices and 8 of them were studied twice in the machine where the model was developed. The phantom was analysed in the same equipment and 14 times in the reference machine.Results. FeCl3solutions containing 0.3, 0.5, 0.6, and 1.2 mg Fe/mL were chosen to generate the phantom. The average of the intramachine variability for patients was 10% and for the intermachines 8%. For the phantom the intramachine coefficient of variation was always below 0.1 and the average of intermachine variability was 10% for moderate and 5% for high iron overload.Conclusion. The phantom reproduces the behavior of patients with moderate or high iron overload. The proposed method of calculating liver iron concentration is reproducible in several different 1.5 T systems. |
| Databáze: | OpenAIRE |
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