T lymphocytes are necessary for the peripheral phase of B lymphocyte maturation
| Autor: | Novica M. Milićević |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
B-Lymphocytes
MHC class II Adoptive cell transfer biology business.industry T-Lymphocytes Lymphocyte T cell Lymphocyte Cooperation CD44 Cell Differentiation General Medicine T lymphocyte Molecular biology Rats Rats Nude medicine.anatomical_structure Immature B-Lymphocyte biology.protein Animals Medicine Mature B-Lymphocyte business |
| Zdroj: | Srpski arhiv za celokupno lekarstvo. 136:166-170 |
| ISSN: | 2406-0895 0370-8179 |
| DOI: | 10.2298/sarh08s2166m |
| Popis: | Until recently, B lymphocyte maturation was considered to be independent of the thymus and T lymphocytes. However, using nude animals, which lack the functional thymus, we have shown that T lymphocytes are required for the peripheral phase of B lymphocyte maturation. We showed that the proportion of immature B lymphocyte subsets (CD90highIgMhigh and CD90highIgMlow) was significantly increased, whereas that of mature B lymphocyte subsets (CD90−IgMlow and CD90−IgMhigh) was decreased in the peripheral blood and lymph nodes of nude rats. In addition, the expression of functionally important surface molecules MHC class II, ICAM-1, CD44 and L-selectin was significantly down-regulated both on immature and mature B lymphocyte subsets. The implantation of thymic tissue under the kidney capsule of nude rats alleviated the block in B lymphocyte maturation and normalized of the defective expression of surface molecules. Comparable effects were seen after the adoptive transfer of T lymphocytes. This shows that in nude rats B lymphocytes do not mature properly due to the lack of T cell help and that T lymphocytes are required for the peripheral phase of B lymphocyte maturation, as well as for the appropriate expression of surface molecules. This should be considered when treating patients with T lymphocyte deficiencies. |
| Databáze: | OpenAIRE |
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