In vitro leishmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin
| Autor: | R. Frazzi, Stefania Conti, Valter Magliani, Claudio Avanzini, Dianella Savoia, Luciano Polonelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
medicine.drug_class
Fluorescent Antibody Technique Monoclonal antibody Microbiology Mice Parasitic Sensitivity Tests parasitic diseases medicine Animals Leishmania major Leishmania infantum biology Antibodies Monoclonal Biological activity Mycotoxins biology.organism_classification Antimicrobial Killer Factors Yeast In vitro Antibodies Anti-Idiotypic Culture Media Monoclonal biology.protein Antibody |
| Popis: | The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa. |
| Databáze: | OpenAIRE |
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