Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease

Autor: Oliver Riedel, Elke Kalbe, Raymond Pomponio, Jörg B. Schulz, Rüdiger Hilker-Roggendorf, Daniel Charissé, Alexander Storch, Nele Schmidt, Karsten Witt, Jan Kassubek, Martin Gorges, Simon Baudrexel, Inga Liepelt-Scarfone, Richard Dodel, Christine Schneider, Daniela Berg, Guray Erus, Kathrin Reetz
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Male
Aging
Parkinson's disease
pathology [Cognitive Dysfunction]
Medizin
diagnostic imaging [Cognitive Dysfunction]
Brain Age
Audiology
Neuropsychological Tests
etiology [Cognitive Dysfunction]
Cohort Studies
pathology [Alzheimer Disease]
pathology [Aging]
Cognition
methods [Magnetic Resonance Imaging]
pathology [Brain]
Medicine
psychology [Aging]
Cognitive decline
medicine.diagnostic_test
General Neuroscience
Brain
Parkinson Disease
Pattern classification
Neuropsychological test
Middle Aged
Alzheimer's disease
Executive functions
Magnetic Resonance Imaging
Cohort
Female
complications [Parkinson Disease]
psychology [Parkinson Disease]
diagnosis [Parkinson Disease]
MRI
medicine.medical_specialty
Atrophy
Alzheimer Disease
Dementia
Humans
Cognitive Dysfunction
ddc:610
diagnostic imaging [Brain]
Aged
business.industry
Working memory
medicine.disease
pathology [Parkinson Disease]
Neurology (clinical)
Geriatrics and Gerontology
business
Developmental Biology
Zdroj: Neurobiology of aging 109, 31-42 (2022). doi:10.1016/j.neurobiolaging.2021.08.020
Popis: Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.
Databáze: OpenAIRE
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