Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease
Autor: | Oliver Riedel, Elke Kalbe, Raymond Pomponio, Jörg B. Schulz, Rüdiger Hilker-Roggendorf, Daniel Charissé, Alexander Storch, Nele Schmidt, Karsten Witt, Jan Kassubek, Martin Gorges, Simon Baudrexel, Inga Liepelt-Scarfone, Richard Dodel, Christine Schneider, Daniela Berg, Guray Erus, Kathrin Reetz |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Male
Aging Parkinson's disease pathology [Cognitive Dysfunction] Medizin diagnostic imaging [Cognitive Dysfunction] Brain Age Audiology Neuropsychological Tests etiology [Cognitive Dysfunction] Cohort Studies pathology [Alzheimer Disease] pathology [Aging] Cognition methods [Magnetic Resonance Imaging] pathology [Brain] Medicine psychology [Aging] Cognitive decline medicine.diagnostic_test General Neuroscience Brain Parkinson Disease Pattern classification Neuropsychological test Middle Aged Alzheimer's disease Executive functions Magnetic Resonance Imaging Cohort Female complications [Parkinson Disease] psychology [Parkinson Disease] diagnosis [Parkinson Disease] MRI medicine.medical_specialty Atrophy Alzheimer Disease Dementia Humans Cognitive Dysfunction ddc:610 diagnostic imaging [Brain] Aged business.industry Working memory medicine.disease pathology [Parkinson Disease] Neurology (clinical) Geriatrics and Gerontology business Developmental Biology |
Zdroj: | Neurobiology of aging 109, 31-42 (2022). doi:10.1016/j.neurobiolaging.2021.08.020 |
Popis: | Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. |
Databáze: | OpenAIRE |
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