Efficient and 'Green' Synthetic Route to Imidazo[1,2‑a]pyridine by Cu(II)–Ascorbate-Catalyzed A3‑Coupling in Aqueous Micellar Media

Autor: Dharmendra Das, Mainak Banerjee, Amrita Chatterjee, Zigmee T. Bhutia
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: ACS Omega, Vol 4, Iss 3, Pp 4481-4490 (2019)
ISSN: 2470-1343
Popis: An efficient and environmentally sustainable method for the synthesis of imidazo[1,2-a]pyridine derivatives by domino A3-coupling reaction catalyzed by Cu(II)-ascorbate was developed in aqueous micellar media in the presence of sodium dodecyl sulfate (SDS). The catalyst, a dynamic combination of Cu(II)/Cu(I), was generated in situ in the reaction mixture by mixing CuSO4 with sodium ascorbate and aided a facile 5-exo-dig cycloisomerization of alkynes with the condensation products of 2-aminopyridines and aldehydes to afford a variety of imidazo[1,2-a]pyridines in good overall yields. A simple experimental setup, water as the "green" medium, and inexpensive catalyst and auxiliary are some of the merits of this protocol.
Databáze: OpenAIRE