Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes

Autor:	Sahar F. Shaban, Asmaa A. A. Kattaia, Nashwa S. Wahba, Sara A. Kandeel
Rok vydání:	2016
Předmět:	inorganic chemicals 0301 basic medicine medicine.medical_specialty Metal Nanoparticles Nanoparticle chemistry.chemical_element Zinc Streptozocin Diabetes Mellitus Experimental Pathology and Forensic Medicine law.invention 03 medical and health sciences Structural Biology law Internal medicine Diabetes mellitus medicine Animals Pancreas Chemistry technology industry and agriculture medicine.disease Streptozotocin Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Histopathology Zinc Oxide Electron microscope Pancreatic injury medicine.drug
Zdroj:	Ultrastructural Pathology. 40:358-373
ISSN:	1521-0758 0191-3123
Popis:	Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662615cb99e60401c5b41b0db8311ced https://doi.org/10.1080/01913123.2016.1246499 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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