The impact of chemotherapy on male fertility: a survey of the biologic basis and clinical aspects
| Autor: | Markus Müller, Mark Schrader, Kurt Miller, Bernd Straub |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Offspring Antiandrogens medicine.medical_treatment media_common.quotation_subject Fertility Biology Toxicology Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Spermatogenesis Infertility Male Testosterone media_common Azoospermia Cisplatin Chemotherapy medicine.disease Paternal Exposure Immunology Hormone therapy medicine.drug |
| Zdroj: | Reproductive Toxicology. 15:611-617 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/s0890-6238(01)00182-4 |
| Popis: | The introduction of cisplatin-based polychemotherapy has led to cure rates of up to 90% for the most frequent malignant diseases seen in young men. In view of these high cure rates, increasing clinical importance is now being attached to chemotherapy-induced fertility disorders. Comparative studies examining the impact of cytotoxic chemotherapy on gametogenesis demonstrate significant cytostatic- and dose-specific differences. The extensive literature on possible teratogenic effects of chemotherapy provides no evidence suggesting that offspring of patients with a history of chemotherapy have an increased risk of malformations. However, these studies, the scope and follow-up of which may still be inadequate, have failed to eliminate the fear of such risk. Hormonal protection from chemotherapy-induced testicular damage has thus far succeeded only in animal models pretreated by application of gonadotropin-releasing hormone agonists combined with nonsteroidal antiandrogens or testosterone plus 17 beta-estradiol. The same holds true for hormone therapy aimed at stimulating the recovery of spermatogenesis after chemotherapy-induced testicular damage. Cryopreservation of germ cells can be suggested to patients undergoing cytostatic therapy. In some cases, testicular extraction of spermatozoa can also be offered as a novel approach. |
| Databáze: | OpenAIRE |
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