Relationship between average leucocyte telomere length and the presence or severity of idiopathic dilated cardiomyopathy in black Africans

Autor:	Andrew R. Raymond, Pinhas Sareli, Richard Brooksbank, Angela J. Woodiwiss, Gavin R. Norton
Rok vydání:	2013
Předmět:	Adult Cardiomyopathy Dilated Male medicine.medical_specialty Pathology Cardiomyopathy Black People Real-Time Polymerase Chain Reaction Severity of Illness Index Ventricular Function Left Coronary artery disease Internal medicine Severity of illness Idiopathic dilated cardiomyopathy Leukocytes Humans Medicine skin and connective tissue diseases Ejection fraction business.industry Confounding Stroke Volume Stroke volume Middle Aged Telomere medicine.disease Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business
Zdroj:	European Journal of Heart Failure. 15:54-60
ISSN:	1388-9842
DOI:	10.1093/eurjhf/hfs147
Popis:	Aims A reduced average leucocyte telomere length is associated with ischaemic heart failure. Whether this relationship represents a cause or consequence of heart failure or is attributed to associated risk factors and coronary artery disease is uncertain. We evaluated if average leucocyte telomere length is associated with idiopathic dilated cardiomyopathy (IDC) or its severity. Methods and results We compared average leucocyte telomere length in 223 patients with heart failure due to IDC and 227 healthy controls of black African ancestry. We also evaluated the relationship between average leucocyte telomere length and left ventricular ejection fraction (LVEF). LVEF was determined using echocardiography and radionuclide multiple-gated acquisition (MUGA) scan in patients with IDC. Relative leucocyte telomere length (T/S) was measured using a quantitative real-time polymerase chain reaction assay. Log T/S was negatively correlated with age in patients with IDC (P = 0.0007) and in controls (P = 0.030), and with alcohol consumption (P = 0.032) and regular smoking (P = 0.021) in patients with IDC. Log T/S did not differ between IDC and control groups either before (P = 0.11) or after (IDC = 0.071 ± 0.187, control = 0.071 ± 0.187, P = 0.99) adjustments for confounders. Log T/S was not associated with echocardiographic (P = 0.47) or MUGA (P = 0.99) LVEF or LV end-diastolic diameter (LVEDD) (P = 0.34) in patients with IDC. With adjustments for age, sex, alcohol consumption, and smoking, log T/S was similarly not associated with echocardiographic (P = 0.60) or MUGA (P = 0.91) LVEF or LVEDD (P = 0.53) in patients with IDC. Conclusions Average relative leucocyte telomere length is not associated with IDC or its severity in groups of black African ancestry.
Databáze:	OpenAIRE
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