The pituitary-adrenal axis in idiopathic retinal vasculitis
| Autor: | M J Wheeler, E M Graham, C Lowy, H E Palmer, G R Wallace, Miles Stanford |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Vasculitis Cortisol secretion endocrine system medicine.medical_specialty Cortisol awakening response Hydrocortisone Prednisolone Anti-Inflammatory Agents Drug Resistance Pituitary-Adrenal System Cellular and Molecular Neuroscience chemistry.chemical_compound Dehydroepiandrosterone sulfate Retinal Diseases Internal medicine medicine Humans Prospective Studies Retina Dehydroepiandrosterone Sulfate Retinal vasculitis business.industry Retinal Vessels medicine.disease Sensory Systems Ophthalmology medicine.anatomical_structure Endocrinology chemistry Female business Scientific Correspondence hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | British Journal of Ophthalmology. 83:1393-1395 |
| ISSN: | 0007-1161 |
| Popis: | AIMS—To determine whether patients with idiopathic retinal vasculitis have altered production of cortisol and dehydroepiandrosterone sulphate (DHEA-S), and whether differences in these variables occur between those who are sensitive (SS) and resistant (SR) to steroids. METHODS—20 patients with retinal vasculitis (off treatment) and 10 control subjects were prospectively recruited. Morning cortisol and DHEA-S levels were measured, and cortisol secretion rates and short synacthen tests (SST) carried out in patients before treatment, when on prednisolone 20 mg/day, and in controls. RESULTS—There were no differences in any variables between patients and controls. For retinal vasculitis patients pretreatment, the SST was lower in SR patients (p=0.02). More of the SR patients had ischaemic retinal vasculitis ( p |
| Databáze: | OpenAIRE |
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