The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction
| Autor: | Tatiana Teixeira Torres, Raquel Dietsche Monfardini, Cláudia G. Belém, Gisele Antoniazzi Cardoso, Maite Arana, Filipe Viegas, Juliane Menezes, Yanel A. Volonté, Fabiana Heredia, Andre Macedo, Magdalena Fernandez-Acosta, Andres Garelli, César S. Mendes, Marcos J. Dibo, Alisson M. Gontijo, Joana Pereirinha, Malwina Kotowicz, Kohtaro Tanaka, Andreia P. Casimiro, Facundo H. Prado Spalm |
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| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetics of the nervous system Chemistry(all) medicine.medical_treatment metabolism [Receptors G-Protein-Coupled] General Physics and Astronomy NEUROFISIOLOGIA metabolism [Drosophila] Receptors G-Protein-Coupled Lgr3 protein Drosophila chemistry.chemical_compound 0302 clinical medicine genetics [Drosophila Proteins] metabolism [Drosophila melanogaster] Morphogenesis Drosophila Proteins media_common Neurons genetics [Drosophila melanogaster] Multidisciplinary Relaxin Metamorphosis Biological metabolism [Relaxin] drug effects [Morphogenesis] genetics [Morphogenesis] medicine.anatomical_structure Drosophila melanogaster metabolism [Neurons] Larva metabolism [Epidermis] Behavioural genetics Intercellular Signaling Peptides and Proteins Drosophila Biological metamorphosis ddc:500 Ecdysone Pupariation media_common.quotation_subject Science Neurophysiology metabolism [Drosophila Proteins] Signal Induction Physics and Astronomy(all) Biology metabolism [Larva] General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences medicine metabolism [Epidermal Cells] Animals Metamorphosis pharmacology [Ecdysone] Epidermis (botany) genetics [Receptors G-Protein-Coupled] Biochemistry Genetics and Molecular Biology(all) fungi insulin-like peptide 8 Drosophila General Chemistry Steroid hormone 030104 developmental biology chemistry Epidermal Cells genetics [Ecdysone] Neuron Epidermis Neuroscience 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Nature Communications 12(1), 3328 (2021). doi:10.1038/s41467-021-23218-5 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-021-23218-5 |
| Popis: | Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling. Pupariation in Drosophila is triggered by the steroid-hormone ecdysone and requires coordination between associated behavioral and body-reshaping motor subprograms. The authors show that coordination requires ecdysone-dependent Dilp8-Lgr3 signaling between the cuticle epidermis and interneurons. |
| Databáze: | OpenAIRE |
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