Mother's Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
| Autor: | Ewa Łoś-Rycharska, Tomasz Grzybowski, Marta Gorzkiewicz, Aneta Krogulska, Marcin Gołębiewski, Marcin Sikora |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allergy
skin Breastfeeding Context (language use) Pilot Projects Article Dermatitis Atopic Feces dysbacteriosis/microbial imbalance Food allergy mother’s milk Medicine Humans TX341-641 Microbiome Least-Squares Analysis Phylogeny food allergy Nutrition and Dietetics Bacteria Milk Human atopic dermatitis business.industry Nutrition. Foods and food supply Incidence (epidemiology) Microbiota Discriminant Analysis Infant Atopic dermatitis Biodiversity medicine.disease 16S rRNA sequencing Immunology Female business Food Hypersensitivity Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 3600, p 3600 (2021) Volume 13 Issue 10 |
| ISSN: | 2072-6643 |
| Popis: | The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Therefore, we aimed at finding differences between the fecal and skin microbiomes of FA and AD patients in the context of breastfeeding, by means of the Illumina sequencing of 16S rRNA gene fragment libraries amplified from the total DNA isolated from samples collected from allergic and healthy infants. We also analyzed milk samples from the mothers of the examined children and searched for patterns of incidence suggesting milk influence on an infant’s allergy status. Here we show that a mother’s milk influences her child’s fecal and skin microbiomes and identify Acinetobacter as the taxon whose abundance is correlated with milk and child-derived samples. We demonstrate that breastfeeding makes allergic children's fecal and skin communities more similar to those of healthy infants than in the case of formula-feeding. We also identify signature taxa that might be important in maintaining health or allergy development. |
| Databáze: | OpenAIRE |
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