Effects of lanreotide, a somatostatin analogue, on postprandial gastric functions and biliopancreatic secretions in humans
| Autor: | N. Vidon, S. Chaussade, J. Blumberg, P. Sogni, P. Nepveux, A. Lamrani, F. Catus |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Lanreotide Peptides Cyclic Gastroenterology Polyethylene Glycols Gastric Acid chemistry.chemical_compound Bolus (medicine) Anti-Infective Agents Gastrointestinal Agents Sulfapyridine Internal medicine medicine Humans Single-Blind Method Pharmacology (medical) Gastrointestinal Transit Infusions Intravenous Pancreas Pharmacology Cross-Over Studies Gastric emptying business.industry digestive oral and skin physiology Hydrogen-Ion Concentration Postprandial Period Short bowel syndrome medicine.disease Perfusion Sulfasalazine Somatostatin Postprandial Endocrinology Gastric Emptying chemistry Pancreatic juice Regression Analysis Gastric acid business |
| Zdroj: | British Journal of Clinical Pharmacology. 43:65-70 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1997.tb00139.x |
| Popis: | Aims Lanreotide is a novel synthetic somatostatin analogue. A long-acting formulation of lanreotide has been shown to be effective for the treatment of gastroentero-pancreatic hormone-producing tumours but effects on postprandial digestive and absorptive functions remain obscure. The aim of the present study was to evaluate the effects of intravenous lanreotide on gastric and biliopancreatic secretions in man as well as the absorption of nutrients and the duodeno-caecal transit time after ingestion of an homogenized meal (500 kcal, 55% carbohydrates, 15% proteins, 30% lipids). Methods Eight healthy male volunteers were studied on two occasions within a 2 weeks interval, using a perfusion method. They received in single-blind and random order continuous i.v. infusion of either placebo or lanreotide (100 μg h−1 after a bolus of 100 μg 15 min before the beginning of the study). Results Lanreotide significantly decreased gastric acid secretion (90%) for the initial 3 h period. Gastric emptying was not significantly molfied by lanreotide infusion. Compared with placebo, lanreotide almost completely abolished both bile salts and lipase responses to the meal. It largely increased the duodeno-caecal transit time and decreased significantly the duodenal absorption of carbohydrates and triglycerides. Conclusions Since lanreotide has powerful effects on gastrointestinal functions, it could be useful in the prevention or in the treatment of pancreatic and bowel fistulas as well as short bowel syndrome. |
| Databáze: | OpenAIRE |
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