Lipoprotein(a) Plasma Concentrations, Apolipoprotein (a) Polymorphism and Family History of Coronary Heart Disease in Patients with Essential Hypertension
| Autor: | Diego Geroldi, Paola Buscaglia, Stefania Mariotti, Sandra Savino, Giorgio Finardi, Adriana Garzaniti, Carmine Gazzaruso, Graziella Bonetti, Aura Jucci |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Epidemiology Coronary Disease Enzyme-Linked Immunosorbent Assay Apoprotein(a) Essential hypertension Nuclear Family Internal medicine Familial predisposition Humans Medicine In patient Family history Nuclear family Polymorphism Genetic biology business.industry Lipoprotein(a) Middle Aged medicine.disease Electrophoresis Gel Pulsed-Field Blotting Southern Apolipoproteins Phenotype Endocrinology Hypertension biology.protein Regression Analysis Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | European Journal of Cardiovascular Prevention & Rehabilitation. 3:191-197 |
| ISSN: | 1741-8275 1741-8267 |
| DOI: | 10.1177/174182679600300210 |
| Popis: | AIM The purpose of the study was to investigate lipoprotein (a) (Lp(a)) levels and apolipoprotein (a) (apo(a)) phenotypes, and their relationship with a family history of coronary heart disease (CHD) in patients with essential hypertension (EH). METHODS One hundred and eight newly diagnosed patients with mild to moderate EH and 159 controls were studied. Lp(a) levels were determined with an ELISA method. Apo(a) isoforms were identified by a capillary immunoblotting technique. RESULTS Lp(a) levels and frequency distribution of apo(a) isoforms did not show significant differences between patients and controls. Lp(a) levels in hypertensives with a family history of CHD were significantly higher than in those without a family history of CHD (P < 0.01). Hypertensives with a family history of CHD showed significantly different frequencies of apo(a) isoforms to those without a family history of CHD (P < 0.05). In EH patients with a family history of CHD, apo(a) isoforms of low molecular weight (MW) had a higher prevalence (62.6%), while in hypertensives without a family history of CHD, apo(a) isoforms of high MW were prevalent (81.6%); the difference between the two subgroups was significant (P < 0.001). Multivariate analysis showed that both Lp(a) levels and apo(a) isoforms of low MW are significant variables in distinguishing between the subgroups. CONCLUSIONS Lp(a) levels and apo(a) phenotypes do not differ between hypertensives and controls. High Lp(a) levels and apo(a) isoforms of low MW are strongly associated with a family history of CHD in hypertensives. The quantification of Lp(a) levels and the characterization of apo(a) phenotypes may be used for assessment of familial predisposition to CHD in hypertensives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|