EFFECT OF CHEMICAL SYMPATHECTOMY AND GANGLION BLOCKADE ON ANGIOTENSIN-STIMULATED FLUID ABSORPTION IN THE RAT JEJUNUM
| Autor: | Kenneth A. Munday, P. G. Dorey, Judith A. Poat, Parsons Bj, Mary E. Upsher |
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| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Endocrinology Diabetes and Metabolism Pentolinium Tartrate Hydroxydopamines Norepinephrine Endocrinology Phentolamine Internal medicine Extracellular fluid medicine Animals Oxidopamine Chemistry Angiotensin II Sympathectomy Chemical Dopamine antagonist Rats Inbred Strains Fluid transport Rats Jejunum Intestinal Absorption Extracellular Space Sulpiride medicine.drug |
| Zdroj: | Journal of Endocrinology. 91:205-211 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.0910205 |
| Popis: | A study has been made of the effects of chemical sympathectomy and ganglion blockade on the responses of rat jejunum in vivo to intravenous doses of angiotensin and noradrenaline capable of stimulating fluid transport. Pretreatment with 6-hydroxydopamine (chemical sympathectomy) or pentolinium tartrate (ganglion blockade) abolished the stimulatory actions of angiotensin II but left the responses to noradrenaline unimpaired. Dopamine, like noradrenaline, stimulated fluid transport but this response required very high dopamine infusion rates, was refractory to the dopamine antagonist sulpiride and was inhibited by the α-blocker phentolamine. The possible interaction between angiotensin and the intestinal sympathetics is discussed with reference to control of extracellular fluid volume. |
| Databáze: | OpenAIRE |
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