Asymmetrical Modulation of Immune Reactivity in Left- and Right-Biased Rats After Ipsilateral Ablation of the Prefrontal, Parietal and Occipital Brain Neocortex
| Autor: | Snežana Milanović, Branislav D. Janković, Anica Nikoliç, Srdjan M. Vlajkovic, Vera Nikolić |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Rotation Neuroimmunomodulation Central nervous system Prefrontal Cortex Posterior parietal cortex Functional Laterality Parietal Lobe Internal medicine Cortex (anatomy) medicine Animals Brain asymmetry Rats Wistar Prefrontal cortex Neocortex business.industry General Neuroscience Serum Albumin Bovine General Medicine Anatomy Rats medicine.anatomical_structure Endocrinology Delayed hypersensitivity Antibody Formation Laterality Immunization Occipital Lobe business |
| Zdroj: | International Journal of Neuroscience. 78:123-134 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.3109/00207459408986051 |
| Popis: | We report here on the lateralized brain immunomodulation in male Wistar rats, a phenomenon related to the rotational bias of animal and the site of cortical lesion. Rats assigned to left- and right-rotators in a cylindrical Plexiglass rotometer were subjected to the ablation of the ipsilateral prefrontal cortex (PFC), parietal cortex (PC) and occipital cortex (OC) and sensitized with bovine serum albumin (BSA) in complete Freund's adjuvant. Intact and sham-lesioned left-biased animals demonstrated increased Arthus and delayed hypersensitivity skin reactions and antibody production to BSA in comparison with corresponding right-biased animals. PFC ablation decreased humoral and cellular immune responses to BSA in left- but increased in right-biased rats. Lesioning of PC decreased humoral immune reactions in left- but increased in right-rotating animals. OC ablation failed to produce immunological abnormalities. These results suggest that immunopotentiation is associated with the left neocortex, and immunosuppression with the right neocortex. The prefrontal cortex appears to be particularly associated with immune reactions. |
| Databáze: | OpenAIRE |
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